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Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin–angiotensin system

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Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin–angiotensin system

Revista Hypertension ResearchPor: Lenka Hošková, Ivan Málek, Josef Kautzner, Eva Honsová, Richard P E van Dokkum, Zuzana Husková, Alžbeta Vojtíšková, Šárka Varcabová, Ludek Cervenka y Libor Kopkan.  Hypertension Research (2014) 37, 724–732.

Chronic immunosuppressive therapy is often complicated by the development of both arterial hypertension and renal dysfunction. The principal aim of this study was to assess the effects of dual inhibition of renin–angiotensin system (RAS) and other antihypertensive treatment on blood pressure and renal function in normotensive and hypertensive Fawn-Hooded (FH) strains during chronic calcineurin inhibitor (CNI) administration.

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