Los trabajos y opiniones que aquí se exponen son orientadores de lo que se publica en Cuba y en el mundo sobre aspectos relevantes de la hipertensión arterial.


Effect of Chlorthalidone, Amlodipine, and Lisinopril on Visit-to-Visit Variability of Blood Pressure: Results From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

Por:  Paul Muntner PhD, Emily B. Levitan PhD, Amy I. Lynch PhD, Lara M. Simpson PhD, Jeffrey Whittle MD, Barry R. Davis MD, PhD, John B. Kostis MD, Paul K. Whelton MD y Suzanne Oparil MD.  The Journal of Clinical Hypertension, volume 16, Issue 5, pages 323–330, May 2014.

Few randomized trials have compared visit-to-visit variability (VVV) of systolic blood pressure (SBP) across drug classes. The authors compared VVV of SBP among 24,004 participants randomized to chlorthalidone, amlodipine, or lisinopril in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). VVV of SBP was calculated across 5 to 7 visits occurring 6 to 28 months following randomization.

Artículos Originales

Blood pressure variability assessed by home measurements: a systematic review

revista-hypertension-researchPor:  George S Stergiou, Angeliki Ntineri, Anastasios Kollias, Takayoshi Ohkubo, Yutaka Imai y Gianfranco Parati.  Hypertension Research (2014) 37, 565–572.

Accumulating evidence suggests that day-by-day blood pressure (BP) variability assessed using self-measurements by patients at home (HBPV) provides useful information beyond that of average home BP. This systematic review summarizes the current evidence on day-by-day HBPV. A systematic literature search (PubMed) revealed 22 eligible articles. Independent prognostic value of day-by-day HBPV for cardiovascular events and total mortality was demonstrated in two outcome studies, whereas novel indices of variability had minimal or no independent prognostic ability.


Yet Another Study Reports Poor Control of Elevated Blood Pressure

ComentadoPor: Lewis H. Kuller.  American Journal of Hypertension Volume 27, Issue 6, Pp. 773-774.

The article by Sorlie et al. (this issue) provides estimates of the prevalence of hypertension and of awareness, treatment, and control among the Hispanic community. Previous publications from this study have described the study design and recruitment and baseline measurements and the distribution of risk factors and prevalent cardiovascular disease. The reports documented very substantial variability in the prevalence of hypertension by specific Hispanic groups and communities.

Factores de Riesgo

Antihypertensive drug classes have different effects on short-term blood pressure variability in essential hypertension

Riesgo cardiovascularPor: Natacha Levi-Marpillat, Isabelle Macquin-Mavier, Anne-Isabelle Tropeano, Gianfranco Parati y Patrick Maison.  Hypertension Research (2014) 37, 585–590.

Increased blood pressure variability (BPV) contributes to end-organ damage, cardiovascular events and mortality associated with hypertension. In a cohort of 2780 hypertensive patients treated by either calcium channel blockers (CCBs), diuretics, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs) or ß-blockers alone or in combination, we compared indices of short-term BPV according to the different treatments. Short-term BPV was calculated as the standard deviation (s.d.) of 24?h, daytime or nighttime systolic blood pressure and diastolic blood pressure (SBP and DBP).

Revisiones sistemáticas

Sex differences in response to angiotensin II receptor blocker-based therapy in elderly, high-risk, hypertensive Japanese patients: a subanalysis of the OSCAR study

Revisiones sistematicasPor: Kunihiko Matsui, Shokei Kim-Mitsuyama, Hisao Ogawa, Tomio Jinnouchi, Hideaki Jinnouchi y Kikuo Arakawa for the OlmeSartan Calcium Antagonists Randomized (OSCAR) Study Group.  Hypertension Research (2014) 37, 526–532.

Essential hypertension is a common comorbid condition and risk factor for cardiovascular events; in addition to lifestyle modification, drug therapy is the main treatment strategy. Although there are indications for specific classes of antihypertensive drugs for particular patients, such as diuretics for hypertensive African Americans,1 there is no uniform agreement on the type of drug(s) that should be used when physicians choose an antihypertensive drug for newly diagnosed patients without specific indications for those drugs.  Recently, many evidence-based clinical practice guidelines from various clinical fields have been published to improve the quality of patient care.


Ethnic differences in genetic predisposition to  hypertension

InvestigacionesPor: Norihiro Kato.  Hypertension Research (2012) 35, 574–581.

Genetic, environmental and demographic factors and their interaction determine an individual’s risk for hypertension. Despite considerable efforts to investigate the genetic basis of hypertension, or elevated blood pressure (BP) levels, the inherently complex nature hampered progress in the elucidation of the genes involved and yielded little success until 2009 when two consortia-based meta-analyses of genome-wide association (GWA) studies involving 30?000–40?000 samples in the discovery stage identified a total of 13 independent loci significantly associated with BP in populations of European descent.

Artículos interesantes

En esta sección les exponemos algunos artículos publicados sobre la hipertensión arterial.    

  De varias Revistas


Hypertension in Obese Type 2 Diabetes Patients is Associated with Increases in Insulin Resistance and IL-6 Cytokine Levels: Potential Targets for an Efficient Preventive Intervention

Por:  Ljiljana Lukic , Nebojsa M. Lalic, Natasa Rajkovic, Aleksandra Jotic, Katarina Lalic, Tanja Milicic, Jelena P. Seferovic, Marija Macesic y Jelena Stanarcic Gajovic.   Int. J. Environ. Res. Public Health 2014, 11(4), 3586-3598.


Decreased renal function in hypertensive emergencies

Por: U Derhaschnig, C Testori, E Riedmueller, E L Hobl, F B Mayr y  B Jilma.  Journal of Human Hypertension (2014) 28, 427–431.


El uso de los beta-bloqueadores y el Eighth Joint National Committee


Por: Alberto Morales Salinas.  Revista Finlay de enfermedadades no transmisibles, vol. 4, núm. 1 (2014).





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