Association of Urinary Sodium and Potassium Excretion with Blood Pressure

Association of Urinary Sodium and Potassium Excretion with Blood Pressure

Por: Andrew Mente, Ph.D., Martin J. O'Donnell, M.B., Ph.D., Sumathy Rangarajan, M.Sc., Matthew J. McQueen, M.B., B.Ch., Paul Poirier, M.D., Ph.D., Andreas Wielgosz, M.D., Ph.D., Howard Morrison, Ph.D., Wei Li, Ph.D., Xingyu Wang, Ph.D., Chen Di, B.Sc., Prem Mony, M.D., Anitha Devanath, M.D., Annika Rosengren, M.D., Aytekin Oguz, M.D., Katarzyna Zatonska, M.D., Ph.D., Afzal Hussein Yusufali, M.D., P N, Et Al.  Engl J Med 2014; 371:601-611August 14, 2014DOI: 10.1056/NEJMoa1311989.

Hypertension affects 1 billion people and is considered to be a leading cause of death, stroke, myocardial infarction, congestive heart failure, and chronic renal impairment.1-4 Sodium intake is reported to be a modifiable determinant of hypertension.5,6 The International Study of Salt and Blood Pressure (INTERSALT),7 but not another large study,8 showed a modest association between higher levels of sodium intake and higher blood pressure. However, INTERSALT was not large enough to determine whether the association varied according to region, participant characteristics, or levels of sodium or potassium intake.