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Telmisartan activates endogenous peroxisome proliferator-activated receptor-d and may have anti-fibrotic effects in human mesangial cells

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Telmisartan activates endogenous peroxisome proliferator-activated receptor-d and may have anti-fibrotic effects in human mesangial cells

ComentadoPor: Daisuke Mikami, Hideki Kimura, Kazuko Kamiyama, Kunio Torii, Kenji Kasuno, Naoki Takahashi, Haruyoshi Yoshida y Masayuki Iwano.   Hypertension Research (2014) 37, 422–431.

Telmisartan, an angiotensin II receptor type 1 blocker (ARB), was recently reported to promote lipolysis in mice by acting as a peroxisome proliferator-activated receptor (PPAR)-d activator, although in clinical studies, it has also been recognized to activate PPAR-? as a major cause of its pleiotropic actions. The aim of this study was to investigate whether telmisartan activates endogenous PPAR-d and thereby exerts anti-fibrotic effects in human mesangial cells (HMC).