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Differences in vascular reactivity between pregnant women with chronic hypertension and preeclampsia

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Differences in vascular reactivity between pregnant women with chronic hypertension and preeclampsia

ComentadoPor: Toshitaka Mori, Kazushi Watanabe, Ai Iwasaki, Chiharu Kimura, Hiroshi Matsushita, Koichi Shinohara y Akihiko Wakatsuki.  Hypertension Research (2014) 37, 145–150.


The purpose of this study was to evaluate the distinct pathogenic mechanisms underlying chronic hypertension in pregnancy and preeclampsia in terms of oxidative stress and vascular reactivity. A total of 17 women with uncomplicated pregnancies, 30 women with preeclampsia and 17 women with chronic hypertension were evaluated. We measured serum derivatives of reactive oxygen metabolites (d-ROMs; marker of oxygen free radicals), flow-mediated vasodilation (FMD; marker of endothelial function) and intima-media thickness in the carotid artery (IMT; marker of atherogenesis) during pregnancy and 1 month after delivery.